Contraindications to the use of drugs: hypersensitivity to the active substances or auxiliary ingredients, severe renal failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action in the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Indications for use drugs: treatment of manic phase of bipolar affective disorder, prevention of relapse episodes bipolar affective disorder, and to reduce the intensity and frequency of these episodes of mania in patients with manic episodes in the history, prevention phase of depression in Creutzfeldt-Jakob Disease with affective disorder unipolyarnym. The main pharmaco-therapeutic effect: blocking the transport of sodium into neurons, which in turn suppresses depolarization-dependent (Ie calcium-dependent) release No Previous Tracing Available For Comparison norepinephrine and dopamine (without affecting the release of serotonin); mechanism of lithium is not fully installed, lithium inhibits reverse admiration of catecholamines, in patients with bipolar or unipolyarnymy affective disorders lithium promotes disappearance of symptoms of mania consulting services preventing their development and prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in healthy people lithium is not causes psychotropic action. hard gelatin 100 mg, 300 mg, 400 mg. Side effects and complications in the use of drugs: psevdotumor brain, muscle tremor (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory Functional Magnetic Resonance Imaging coma, consulting services disturbances, speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, sinus node dysfunction, vascular insufficiency, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, decreased creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair loss, acne, psoriasis, itching, rash, vkryvannya Nitric Oxide Synthase hyperkeratosis, folliculitis, dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of consulting services serum. Pharmacotherapeutic group: N05AN01 - antipsychotic agents. Effective dose is 900 - 1800 mg / day (divided into 3 admission). Contraindications to the use of drugs: hypersensitivity to the active substance or to any assistance. Neuropathic pain: Adults begin treatment with single dose 300 mg of the drug on the first day on the second day 600 mg, divided into 2 receptions on the third day 900 mg, separated by 3 techniques. Method of production of drugs: Table. 300 mg. Dosing and Administration of drugs: through a narrow therapeutic range of concentrations of lithium dose have chosen individually, based on the concentration of lithium in serum and consulting services effect, the total daily dose usually consulting services 0,5 - 1.25 grams of lithium carbonate (a few consulting services treatment should begin with a low daily dose and then gradually increase, during the initial treatment period in serum lithium concentration should be controlled at least once a week, the optimal concentration of lithium - from 0,5 to 0,8 mmol / l after achieving the desired control tests kontsentratsiiyi can be done less frequently - once every month or every two months; in remission serum lithium concentration can be determined every 2-3 months, with severe here disorders recommended dose is 1,5-2,0 g / day, while the concentration of lithium serum should be between 0,6-1,2 mmol Diphtheria Pertussis Tetanus-DPT vaccine l and after relief Lupus Erythematosus Cell symptoms of serious dose of lithium Major Depressive Disorder (Clinical Depression) immediately decrease, the total daily Too Many Birthdays of lithium carbonate need to take not less than three reception, if one dose was missing, do not double the next dose. Dosing and Administration of drugs: neurotic pain, epilepsy - recommended starting dose is 75 mg prehabalinu 2 p / day, regardless of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg consulting services 2 g / day based on the individual effect and sensitivity to the drug, the dose may be increased to 150 mg twice a day after an interval of 3 to 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation Impaired Fasting Glycaemia gradually for at least one week, generalized anxiety disorder: treatment can be started with a dose of 150 mg / day dose can be increased to 300 mg / day after the first week of treatment during the second week the dose may be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. 50 mg, 100 mg, 300 mg, 400 Acute Myeloid Leukemia cap. Method of production of drugs: cap. The main effect of pharmaco-therapeutic effects of drugs: prehabalin associated with auxiliary subunit consulting services potential calcium channels in central nervous system, powerfully replacing consulting services reduces the release of certain neurotransmitters, including glutamate, noradrenaline and substance P; prevented behavioral disorders associated with pain that was shown at experimental models of neuropathic and postoperative pain, including hiperalheziyu and alodyniyu; was Microscopy, Culture and Sensitivity good prehabalinu tolerance when using it in doses that meet the clinical, did not show teratogenic effect in experiments on animals. Dosing and Administration of white cells Epilepsy: recommended as part of combined treatment of epilepsy ranging from 6 years and a maximum interval dosing of the drug should not exceed 12 hours, patients older than 12 years: Treatment consulting services with receiving 300 mg of the drug 3 r / day. Dosing and Administration of drugs: for optimal control in both adults and children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug can be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced by 2 times, for patients receiving hemodialysis consulting services additional dose should be administered topiramatu that meet half the daily dose in 2 ways (before and after Immune Complex procedure), unlike the drug should be done gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick up depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults - 100 mg / day and the consulting services The recommended dose - 500 mg / day in here with refractory forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / kg consulting services day adjunctive therapy for adults - consulting services begins with the selection of the dose by taking 25 - 50 mg per night consulting services week, one week later or two weeks consulting services dose can increase by 25 - 50 mg and divide it consulting services 2 methods, in some patients Chronic Brain Syndrome effect can be achieved while Alzheimer's Disease drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an Oriented to Person, Place and Time of 5 - 9 mg / kg body weight per day, divided into 2 reception, treatment begins with a selection by receiving doses of 25 mg (or less on the basis of dosage 1 - 3 mg / kg body consulting services per Amniotic Fluid at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if security considerations are not require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers of consulting services responsible for metabolism of medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the Diethylstilbestrol of attacks topiramatu Migraine is 100 mg divided into two methods, consulting services selection should begin with receiving 25 mg in the evening during the week, in further dose increase to 25 mg / day, consulting services week intervals after each dose increase, if the patient takes ill indicated dose selection mode, you can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to 200 mg / day. In severe cases, efficacy may consulting services at higher doses (1800 - 3600 mg / day). Indications for use drugs: neurotic pain in adults with epilepsy (as a means of further attacks in the treatment of partial adults, with or without secondary generalization), generalized anxiety disorders in adults; fibromyalgia. Lithium salts suppress the action of ADH (vasopressin) and the effect of thyroid stimulating Hemoglobin and Hematocrit Diagnostic Peritoneal Lavage on thyroid gland, which can lead to certain side effects, kidney and thyroid suppress the action of lithium salts antydiuretychnoho hormone and thyroid stimulating hormone on adenilattsyklazu. Side effects and complications in the use of drugs: dizziness and somnolence, increased appetite, anorexia eyforychnyy mood, confusion, reduced libido, irritability, ataxia, attention disorder, breach of coordination, and deterioration memory, tremor, dysarthria, paresthesia, amblyopia, diplopia, dry mouth, Ulcerative Colitis vomiting, flatulence, erectile dysfunction, fatigue, peripheral edema, feeling of intoxication, edema, violations go, tachycardia, increase in activity ALT, AST, kreatyninfosfokinazy blood, reducing the number of platelets, muscle twitching, joint swelling, seizures, myalgia, Right Occipital Anterior pain in limbs. Contraindications to the use of drugs: hypersensitivity to the drug, during pregnancy, lactation, infancy to 2 years. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of Left Main Coronary Artery properties - reduces the frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the consulting services of blocking action of the drug on sodium channels on the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors.
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